PGD - Preimplantation Genetic Diagnosis Petaling Jaya

Preimplantation genetic diagnosis (PGD) is used to analyze embryos genetically before their transfer into the uterus. PGD offers couples at risk the chance to have an unaffected child, without facing termination of pregnancy. Embryos are obtained by in vitro fertilization with intracytoplasmic sperm injection (ICSI) and are biopsied mostly on day 3; blastocyst biopsy is mentioned as a possible alternative. The genetic analysis is performed on one or two blastomeres by fluorescent in situ hybridization (FISH) or micro-array comparative genomic hybridization (MaCGH). The embryo is usually unharmed and can go on to develop just as though these one or two cells were never removed. PGD with IVF, can now prevent couples from having to face the difficulty of giving birth to children with almost any of the genetic defects such as alpha-Thalassaemia, beta-Thalassaemia, Down syndrome, cystic fibrosis, muscular dystrophy, sickle cell anemia, Tay-Sachs, Gaucher’s disease, mental retardation, sex-linked disorder, etc., that are a concern to every woman who ever gets pregnant. With PGD, we can also better understand the problem of recurrent, early miscarriage and the genetic errors that arise in pregnancies in older mothers.

Egg donation or ovum donation is a possible solution for women: who cannot produce eggs due to menopause or have been diagnosed with premature ovarian failure (POF) - also referred to as premature menopause or early menopause above age 37 who have been repeatedly unsuccessful with IVF, particularly if it is known that the infertility is not male factor who carry a genetic disorder they do not wish to pass on to their child who have had multiple unexplained miscarriages